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Acute kidney injury and chronic kidney disease are interconnected, say GW researchers For more than 40 years, physicians have treated diminished kidney work as two distinct syndromes: acute kidney injury and chronic kidney disease . However, latest epidemiologic and mechanistic studies suggest the two syndromes are not distinct entities, but interconnected. Published today in The New England Journal of Medicine, George Washington University researchers call for greater follow-up care of individuals with AKI, who present with CKD later on in life often, and vice versa.