Navy Capt. Edward Kilbane, Army Col. Jeffrey Jackson and Navy Lt. Cmdr. Thomas Luke, are all alumni and faculty of the Uniformed Solutions University of medical Sciences . They, along with retired Navy doctor, Capt. Stephen Hoffman, tuesday published their research, Aug. 29, in the online edition of the Annals of Internal Medication. Related StoriesInfluenza-related pneumonia hospitalizations could be avoided through influenza vaccinationJohns Hopkins doctors desire people to obtain vaccinated against influenza virusAcetaminophen Consciousness Coalition issues security message to customers about flu medicinesThe four researchers analyzed medical literature reported through the Spanish Flu pandemic of 1918 to 1920.Nicolini, J.F. Apperley, H.J. Khoury, M. Talpaz, J. DiPersio, D.J. DeAngelo, E. Abruzzese, D. Rea, M. Baccarani, M.C. Gambacorti-Passerini, S. Wong, S. Lustgarten, V.M. Rivera, T. Clackson, C.D. Turner, F.G. Haluska, F. Guilhot, M.W. Deininger, A. Hochhaus, T. Hughes, J.M. Goldman, N.P. Shah, and H. Although preliminary response rates are high, imatinib fails in up to 40 percent of patients due to disease resistance, frequently due to BCR-ABL kinase domain mutations or unacceptable side effects.1,2 Sufferers who discontinue imatinib may have a reply to second-generation tyrosine kinase inhibitors. However, 37 to 52 percent of patients don’t have a reply,3-8 and 23 to 26 percent of individuals have a short major cytogenetic response that is lost by 24 months.3,9 The prognosis for these patients is quite poor.