This study, currently being tested in all solid tumors, it is at the UM Comprehensive Cancer Center, National Cancer Institutethe Mayo Clinic offered. Ascenta has also recently opened a second study of AT-406 with high-risk acute myeloid leukemia at the UM Comprehensive Cancer Center. Several further clinical trials are planned. – ‘Our research goal and our passion is to science and science and discovery into new and effective medicines to patients,’says Wang.
Disclosure: Shaomeng Wang owns shares and stock options in Ascenta and serves as a consultant for Ascenta.Reference: Journal of Medicinal Chemistry, doi: / 10.1021/jm101505d.
In animal models, the drug shrank tumors but caused few side effects. The drug was developed by the mouth, the researchers say, it will be made than traditional than conventional intravenous chemotherapy.According to the authors, these new insights mGlu2 / 3 receptors to identify addicted to as an a very promising treat target for difficult of cocaine individuals. Study treatment target potential limit mGlu5 receptor early cocaine abuse. This type of study shows an aspect of complexity that in pharmacotherapy the pharmacotherapy for treatment of cocaine addiction any type of coke not be equal, ‘said Dr. John Krystal, Editor of Biological Psychiatry. ‘Cocaine exposure to different degrees differing make adjustment into the brain systems. That other profiled effects mGluR2 / 3 agonists and mGluR5 antagonists is interesting and it should be stimulates additional research..
Today, these receptors will be as promising targets for Arzneimittelforschung, with therapeutic potential disturbances variety neurological and psychiatric, including the treatment of drug dependency.
Autonomy cocaine abuse?The authors to a recent study to Biological Psychiatry discover pharmacological strategies for reducing cocaine self-administration in Animal , which may have implications for the treatment of cocaine addiction in humans.. Glutamate is the primary excitatory neurotransmitter in brain at into drug addiction. Metabotropic glutamate receptors are a Family reviews of G – protein-coupled receptors that modulate glutamate transmission. Glutamate is an important neurotransmitter part of learning and memory.