Shorten patients long-term survival.

Many cancer treatments work by disrupting the formation of new blood vessels that feed growing tumors. Agents that block a vessel-promoting element called VEGF have shown promise in human clinical trials. But recent studies in mice show that whenever treatment stops, tumor growth resumes. Now, Yoshiaki Kubota and colleagues discover that blocking a different molecule, called M-CSF, suppressed tumor growth after treatment was stopped sometimes.This study thus provides evidence that bronchoconstriction induces epithelial stress and initiates a tissue response that leads to structural airway changes. This finding not merely offers relevance for asthma but could also provide an description for the remodeling explained in sufferers with chronic cough.31 Since repeated epithelial tension might lead to remodeling, preventing bronchoconstriction itself ought to be an important goal of asthma management. Having less focus on controlling airway caliber may explain why daily inhaled glucocorticoid therapy has not been shown to modify the organic history of lung-function adjustments in preschool-age and school-age children in long-term, potential interventional studies.32,33 Although treating the inflammatory component of asthma may be the first-line method of controlling the disease, bronchial hyperresponsiveness is not normalized by inhaled glucocorticoid therapy frequently, particularly in patients with more severe asthma, and additional therapy is necessary.

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