The EXPLORE study cure.

The EXPLORE study, patients 18 years and older enrolled with signs of AA, MDS syndromes , unclassified MDS and 5q-syndrome), and other bone marrow failure diseases. Are used a first peripheral blood draw for hematological evaluation cure . Patients who tested positive for the PNH clone may be asked to participate in a two-year follow-up the symptoms the symptoms and perform hematologic assessments are. Parker C, Omine M, Richards S, diagnosis and treatment of paroxysmal nocturnal hemoglobinuria. Blood 2005 Dec 1, 106 : 3699-709. Nishimura, Kanakura, RE et al. Clinical course and flow cytometric analysis of paroxysmal nocturnal hemoglobinuria in the United States and Japan. Medicine 2004 May 83 :193-207.

Alexion Announces Explore Clinical Diagnostic Study for paroxysmal nocturnal hemoglobinuria With research indicates that many patients with paroxysmal nocturnal hemoglobinuria undiagnosed for years and that many patients have in collaboration PNH with bone marrow failure disorders, Alexion Pharmaceuticals today announced the introduction of multi-center eXPLORE study to examine the frequency of PNH patients with aplastic anemia , myelodysplastic syndrome and other bone marrow failure disorders. Although the hemolytic blood disorder PNH bone marrow disorders bone marrow diseases, it is often misdiagnosed or undiagnosed in these patients.

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